Navigation Menu

Careers

We Put People First

At Autobahn, our mission, approach and commitments are centered entirely around people…

People affected by CNS disorders, including their families and physicians, who deserve to feel hopeful about their treatment options and future.

People who work tirelessly each day to create life-changing medicines.

People who collaborate with us, not just to improve, but fundamentally transform the lives of patients with CNS disorders.

Group photo of Autobahn team

Our Team

Our team is a group of extraordinarily talented individuals with the passion and commitment required to move mountains. We’re serious about our work but always make sure that we pause to breathe and to recognize that the journey is as important as the destination. Our sunny San Diego location is the perfect environment to help us get outside and take a moment for ourselves.

Contact Us

Our Values

Culture of Integrity

Thoughtful purpose yields trusted outcomes. We abide by an inherent obligation to do the right thing for the right reasons, every time. Our journey is paved by being open, balanced and respectful in all of our actions, engagements and decisions.

Spirited Collaboration

Ambitious goals require teams to collaborate at the highest level – uniting our diverse knowledge, ideas and talents to accomplish a singular mission. Collaboration drives innovation, efficiency and success. It’s also fun!

Results-Driven

We work with exceptional people who do exceptional things. With a bold vision and a can-do attitude, we challenge the notion of what’s possible, not just to meet the needs of those we touch, but to exceed them.

Join us in our mission

As a start-up company, we are always seeking exceptional people who do exceptional things to take us to exceptional levels. Just because we may not have your ideal position posted at this moment, doesn’t mean we won’t have a position matching your talent in the near future.

Autobahn is headquartered in brand new facilities at Alexandria GradLabs in San Diego. In addition to a competitive compensation package that includes equity incentives, we offer a comprehensive benefits package for our employees and their families, which includes:

  • Robust benefits – broad range of medical, dental and vision plans, plus FSA
  • Wellness – free membership to fitness centers and classes
  • Life – unlimited PTO, holidays, discounted tickets
  • Financial security – 401(k) plan, life and disability insurance
  • Having fun – team building events and great GradLabs amenities, including catered lunches and food trucks

Associate Director, Medicinal Chemistry

Join us! We are seeking high-performing individuals who are passionate about science and excited to work in a collaborative environment with an experienced team fueled by a rigorous and entrepreneurial culture. Take part in our mission to restore hope for people affected by CNS disorders.

Apply to Position

About

Autobahn Therapeutics is focused on improving life health for people affected by CNS disorders. Autobahn is leveraging a deep understanding of validated human biology coupled with its brain-targeting chemistry platform to develop thyroid hormone receptor beta agonist therapies that harness the regenerative power of the human body. The company’s pipeline is led by ABX-002 for the treatment of multiple sclerosis and adrenomyeloneuropathy (AMN), a rare genetic disorder.

Autobahn Therapeutics has a deep investor base, anchored by ARCH Venture Partners, and is located in San Diego. For more information, visit www.autobahntx.com

Responsibilities

In this role, the successful candidate will manage internal and external medicinal chemistry efforts of CNS-driven drug discovery programs. This is primarily an office-based position. The role is focused on the generation of novel chemical matter with excellent drug-like properties and partners closely with discovery biology, translational sciences, DMPK, structural biology, and other key functions. Daily activities will include analysis of screening data, compound design, synthetic route planning, scientific direction of synthetic chemistry CROs, and facilitating testing through compound management. Additionally, this role will require regular presentations of rationales, key data, issues, and accomplishments of the chemistry efforts to other members of the cross-functional discovery team and to the broader organization, as necessary.

Requirements

Qualifications 

  • D. in synthetic organic chemistry with 6+ years pharmaceutical medicinal chemistry industrial experience or
  • S. or B.S. in synthetic organic chemistry with 15+ years pharmaceutical medicinal chemistry industrial experience
  • Experience using biological data, structural information, and computational modeling to design novel drug candidates and directing the advancement of chemical scaffolds from early lead identification to development candidate selection
  • Expert understanding of modern medicinal chemistry concepts along with excellent working knowledge of ligand-protein interactions, conformational and structural analysis methods
  • A deep knowledge of biochemical, ADME, physicochemical, and pharmacological principles allowing for the independent design of drug-like molecules
  • Track record of innovation and impact on programs demonstrated through co-inventorship on patents/applications and authorship of publications in peer-reviewed journals
  • Strong skills in gathering, analyzing, and documenting competitive information from sources such as patents, meetings, and primary literature to guide program strategies
  • Excellent oral and written communication skills, including ability to present the rationale, data, issues, and accomplishments of the team

Attributes 

  • Team player with strong interpersonal and communication skills
  • Positive and professional approach with strong time management and organization skills
  • Strong synthetic problem-solving skills with a high level of creativity and productivity

 In addition to a competitive compensation package with stock options, we also offer a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, life, disability and a 401(k) plan.

We foster an environment where all people are afforded the freedom to pursue their passions without regard to race, color, religion, national or ethnic origin, gender (including pregnancy), sexual orientation or expression, age, disability or veteran status or any other characteristics protected by law.

For consideration, please submit your resume and cover letter referencing job 034 to careers@autobahntx.com

Director/Senior Director, CMC

Join Autobahn Therapeutics! We are seeking high-performing individuals who are passionate about science and excited to work in a collaborative environment with an experienced team fueled by a rigorous and entrepreneurial culture. Take part in our mission to restore hope for people affected by CNS disorders.

Apply to Position

About

Autobahn Therapeutics is focused on improving life health for people affected by CNS disorders. Autobahn is leveraging a deep understanding of validated human biology coupled with its brain-targeting chemistry platform to develop thyroid hormone receptor beta agonist therapies that harness the regenerative power of the human body. The company’s pipeline is led by ABX-002 for the treatment of multiple sclerosis and adrenomyeloneuropathy (AMN), a rare genetic disorder.

Autobahn Therapeutics has a deep investor base, anchored by ARCH Venture Partners, and is located in San Diego. For more information, visit www.autobahntx.com

Responsibilities

Reporting to the SVP, Development Operations and Regulatory Affairs the Director, CMC will provide leadership, strategy and oversee execution in advancing small molecules from pre-clinical manufacturing to late-stage clinical trials and eventual registration. They will lead critical scientific, regulatory, and business functions pertaining to drug substance and drug product for Autobahn including authoring of (1) regulatory submissions, (2) development of chemical processes for active pharmaceutical ingredients (APIs), process scale-up, technology transfer and validation of chemical processes and effective management and (3) development of formulation for drug products, process scale-up, technology transfer and validation of formulation processes and effective management of CROs and CMOs to accomplish these activities.

Key Responsibilities

  • Lead scale-up, process development, process engineering, and finalization (validation) of the process for clinical and commercial-scale manufacturing of drug substance.
  • Manage and oversee drug product formulation and process development, optimization, clinical supply and registration batch manufacturing, packaging, and process validation activities including selection of external contract development and manufacturing organizations (CDMOs)
  • Delivery of a successful API manufacturing process validation at CMO.
  • Oversee supply chain, logistics and clinical supply management in support of clinical trials.
  • Establish critical raw material attribute control and in-process control strategies.
  • Maintain in-depth knowledge of chemical steps, manufacturing processes, and quality controls following regulatory guidance and QbD principles in accordance with the cGMP requirements to ensure on-time delivery of the drug product.
  • Ensure that CRO/CDMO activities and other process development activities address drug substance needs for pharmaceutical formulation development, toxicology testing, clinical trials, and commercial launch.
  • Establish the drug substance and drug product formulation and process development strategies based on the project’s Target Product Profile and supporting information.
  • Author/review GMP documentation, i.e. batch records, specifications, and protocols.
  • Oversee the batch manufacturing, intermediate sampling, intermediates, and finished product characterization.
  • Review executed batch records, protocols, and reports related to all GMP operations.
  • Conduct appropriate range finding and critical process parameter studies for the drug substance and drug product preparing for registration and validation batches Responsible for planning, documenting, and overseeing the execution of all relevant PPQ/PPV protocols.
  • Oversee the development and implementation of stage appropriate analytical methods and protocols for timely testing of new drug products, and the designing and initiating of stability studies on selected batches.
  • Work collaboratively with Product Development, Chemistry, Quality Assurance and Regulatory Affairs to ensure a high-quality level of cGMP and the worldwide regulatory guidances are followed.
  • Participate in the compilation of IND/NDA and IMPD/MAA and other regulatory dossiers for global product development.
  • Established and maintain CMC budget for assigned projects.
  • Prepare hiring plan and build team that commesurates with pipeline and planned organizational growth

Requirements

Qualifications

  • Advanced degree in Pharmaceutics, Chemical Engineering, Bioengineering, Chemistry, Pharmaceutical Chemistry or related scientific discipline.
  • 7+ years of experience in the Pharmaceutical or Biotech industry with a focus on small molecule drug development and manufacturing.
  • Strategic oversight and execution in manufacturing DS/DP for all stages of clinical trials.
  • Demonstrated experience in managing API chemical development, process validation, and manufacturing in support of NDA marketing applications and commercial production.
  • Demonstrated track record of delivering candidate(s) into chemical manufacturing and commercialization.
  • A proven track record in developing and scaling up oral solid dosage forms including immediate release, modified, and controlled-release formulations for tablets and capsules from pre-IND through Process Validation using Quality by Design (QbD) concepts and design of experiments (DoE).
  • Extensive experience in product development, clinical supply, and registration batch manufacturing for oral solid dosage product development.
  • Experience in the contract manufacturing environment with an in-depth knowledge of unit operations for small molecule drug products including blending, dry/wet granulation, encapsulation, compression, and tablet coating.
  • Experience as the primary author of relevant sections of INDs and NDAs.
  • Ability to effectively work independently in a team environment and substantial experience with managing external CDMOs to meet timelines within the approved budgets.
  • Track record of building, leading and developing a successful CMC team

Attributes

  • Highly effective written and verbal communication skills
  • Strong interpersonal skills
  • Highly collaborative, self-motivated and team oriented
  • Ability to balance multiple data sources, weigh decisions, and drive progress.
  • Ability to grasp concepts and ideas quickly and thrive in a fast-paced environment
  • Willingness to wear many hats and dig into the work at hand
  • Anticipates potential challenges and develops robust mitigation strategies

In addition to a competitive compensation package with stock options, we also offer a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, life, disability and a 401(k) plan.

We foster an environment where all people are afforded the freedom to pursue their passions without regard to race, color, religion, national or ethnic origin, gender (including pregnancy), sexual orientation or expression, age, disability or veteran status or any other characteristics protected by law.

For consideration, please apply via LinkedIn or submit your resume and cover letter referencing job [032-MED] to careers @ autobahntx . com

Principal Scientist, Neuroscience

We are seeking high-performing individuals who are passionate about science and excited to work in a collaborative environment with an experienced team fueled by a rigorous and entrepreneurial culture. Take part in our mission to restore hope for people affected by CNS disorders.

Apply Now

About

Autobahn Therapeutics is focused on improving life health for people affected by CNS disorders. Autobahn is leveraging a deep understanding of validated human biology coupled with its brain-targeting chemistry platform to develop thyroid hormone receptor beta agonist therapies that harness the regenerative power of the human body. The company’s pipeline is led by ABX-002 for the treatment of multiple sclerosis and adrenomyeloneuropathy (AMN), a rare genetic disorder.

Autobahn Therapeutics has a deep investor base, anchored by ARCH Venture Partners, and is located in San Diego. For more information, visit www.autobahntx.com.

Responsibilities

Join an experienced team with a track record of success! The successful candidate will manage internal and external efforts of CNS driven drug discovery program. This is a lab-based position and responsibilities will include designing, managing, and participating in execution of in vivo experiments to drive drug discovery program. This role will likely have at least one direct report to manage day-to-day execution of studies. It will be imperative that the successful candidate investigate literature and propose new directions for the team to pursue.

Key Responsibilities

  • Design and execute research plans that integrate both disease and pathway approaches.
  • Develop strategic plan to validate novel targets with primary focus on in vivo pharmacology.
  • Develop and validate in vivo pharmacology models for screening and efficacy assessment to support drug discovery.
  • Provide regular presentations of rationales, key data, issues, and accomplishments to members of the cross-functional discovery team and to the broader organization.
  • Manage pharmacology research studies at CROs and external academic collaborators. External pharmacology studies will be strategically integrated to complement internal Discovery efforts and will provide an opportunity for external visibility of Autobahn progress.

Requirements

Education

  • PhD and postdoctoral experience or equivalent in Neuroscience, Pharmacology, Biology or related disciplines with 4+ years of experience in the biotech or pharmaceutical industry

Experience

  • 8-12 years’ experience in industry is preferred
  • Demonstrated success in managing laboratory based staff
  • 4+ years in drug discovery and neurodegenerative disease areas is highly desired
  • Expertise in target identification and validation
  • Proficiency in laboratory bench skills such as RNA analysis, ELISAs, Luminex, Western blotting, IHC and/or quantitative histology is desired
  • Experience with multiple in vivo models of CNS diseases
  • Ability to perform in vivo procedures including drug administration (IP, IV, SC and oral), bleeding, tissue collection, and processing of multiple tissues.
  • Familiarity with quantitative small molecule drug discovery, statistical analysis, and biomarker discovery
  • Experience conducting experiments through external CRO’s
  • Experience writing IND enabling study protocols and reports
  • Strong communication skills including building slide decks and presentation skills

Attributes

  • Strong experimental background and experience in hypothesis-driven biological/translational research with demonstrated ability to execute well-designed, creative experiments.
  • Must be a highly flexible, results oriented, independent self-starter who enjoys working in a fast-paced and dynamic, team-oriented environment.
  • Excellent collaboration, communication, and interpersonal skills are required to engage and be productive within a high achieving team environment.
  • Ability to integrate complex scientific ideas, generate testable hypotheses, and execute broad understanding of drug discovery and development in pre-clinical development
  • Proven scientific/leadership expertise (working in teams, managing people/projects commensurate with a senior level).
  • Strong problem-solving skills with a high level of creativity and productivity

In addition to a competitive compensation package with stock options, we also offer a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, life, disability and a 401(k) plan.

We foster an environment where all people are afforded the freedom to pursue their passions without regard to race, color, religion, national or ethnic origin, gender (including pregnancy), sexual orientation or expression, age, disability or veteran status or any other characteristics protected by law.

For consideration, please apply via LinkedIn or submit your resume and cover letter referencing job 033 to careers @ autobahntx . com

Principal Scientist, DMPK

We are seeking high-performing individuals who are passionate about science and excited to work in a collaborative environment with an experienced team fueled by a rigorous and entrepreneurial culture. Take part in our mission to restore hope for people affected by CNS disorders.

Apply Now

About

Autobahn Therapeutics is focused on improving life health for people affected by CNS disorders. Autobahn is leveraging a deep understanding of validated human biology coupled with its brain-targeting chemistry platform to develop thyroid hormone receptor beta agonist therapies that harness the regenerative power of the human body. The company’s pipeline is led by ABX-002 for the treatment of multiple sclerosis and adrenomyeloneuropathy (AMN), a rare genetic disorder.

Autobahn Therapeutics has a deep investor base, anchored by ARCH Venture Partners, and is located in San Diego. For more information, visit www.autobahntx.com

Responsibilities

In this role, the Principal Scientist, DMPK will manage internal and external DMPK efforts of CNS-driven drug discovery programs. This is primarily an office-based position focused on the design and management of ADME studies aimed at understanding the pharmacokinetic and pharmacodynamic properties of small molecules in concert with partners in Medicinal Chemistry, Discovery Biology, Translational sciences, and other key functions. Daily activities will include experimental design and coordination with external CROs, data analysis and report generation, reviewing and writing regulatory filings and reports. Additionally, this role will require regular presentations of rationales, key data, issues, and accomplishments of DMPK efforts to other members of the cross-functional discovery team and to the broader organization, as necessary.

Requirements

Qualifications

  • D. in drug metabolism, pharmaceutical sciences, analytical chemistry or a related field with at least 4 years of relevant education and experience in a pharmaceutical industry ADME/DMPK laboratory.
  • Experience serving as ADME/PK Lead on discovery and pre-clinical teams—having established DMPK strategies that align with program goals and support the discovery of high-quality drug candidates
  • Experience managing external resources (CRO Partners) to enable timely delivery of quality-controlled data for Discovery and Pre-clinical studies.
  • Track record of leadership in the DMPK field as evidenced by publications in high-impact journals and project influence.
  • Experience communicating DMPK data and their relevance to multidisciplinary project teams, management and external stakeholders, as needed.
  • Experience compiling appropriate data and writing pharmacokinetic sections of regulatory submissions a plus.

Attributes

  • Team player with strong interpersonal and communication skills
  • Positive and professional approach with strong time management and organization skills
  • Deep understanding of DMPK concepts, including pharmacokinetics, transporter kinetics, drug metabolizing enzymes, drug biotransformations, and analytical sciences required.
  • Strong DMPK problem-solving skills with a high level of creativity and productivity

In addition to a competitive compensation package with stock options, we also offer a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, life, disability and a 401(k) plan.

For consideration, please submit your resume and cover letter referencing job 030-MED to careers@autobahntx.com

Research Associate/Senior Research Associcate, In-Vivo Biology

We are seeking high-performing individuals who are passionate about science and excited to work in a collaborative environment fueled by a rigorous and entrepreneurial culture.

Apply Now

About

Autobahn Therapeutics is focused on improving life health for people affected by CNS disorders. Autobahn is leveraging a deep understanding of validated human biology coupled with its brain-targeting chemistry platform to develop thyroid hormone receptor beta agonist therapies that harness the regenerative power of the human body. The company’s pipeline is led by ABX-002 for the treatment of multiple sclerosis and adrenomyeloneuropathy (AMN), a rare genetic disorder.

Autobahn Therapeutics is based in San Diego. For more information, visit www.autobahntx.com

Responsibilities

The successful candidate will be a lab-based Research Associate who will execute in vivo studies (mostly mouse) and complete key ex vivo analyses.  You will be involved in the design, planning and execution, and analysis of in vivo drug discovery studies from conceptualization to completion of all analyses.

Key Responsibilities

  • Execute in vivo and ex vivo experiments from inception through data analysis
  • Develop and optimize assays and new technologies to support novel experimental endpoints
  • Maintain comprehensive records through documentation in electronic lab notebooks

Requirements

Education

  •  BS/MS and 4+ years of relevant experience in drug discovery

Experience

  • Expertise in execution of in vivo studies in rodents (especially mice); skilled in oral dosing and dosing via multiple routes.
  • Proficiency in key ex vivo analytical techniques (ELISAs, RNA analysis, etc..) required
  • High level of attention to detail and planning is key
  • Team player with strong interpersonal and communication skills
  • Ability to prioritize multiple high priority tasks effectively
  • Ability to ready literature to augment study design and execution
  • Positive and professional approach
  • Ability to present to a small group
  • Strong time management and organization skills
  • Role may require weekend work to assure smooth execution of studies

In addition to a competitive compensation package with stock options, we also offer a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, life, disability and a 401(k) plan.

We foster an environment where all people are afforded the freedom to pursue their passions without regard to race, color, religion, national or ethnic origin, gender (including pregnancy), sexual orientation or expression, age, disability or veteran status or any other characteristics protected by law.  For consideration, please submit your resume and cover letter referencing job 035 to careers@autobahntx.com

Autobahn News

News